NIH R01 · 2024
Urotensin II and renal insufficiency in growth-restricted infants.
Intrauterine growth restriction (IUGR) is associated with perinatal organ injury and the risk of developing cardiovascular, renal, and metabolic disorders in later life. Hence, elucidation of the mechanisms that cause early and progressive organ derangement in growth-restricted newborns is necessary to reduce infant and adult morbidity and mortality. Urotensin II (UII), a potent vasoactive peptide modulates renal function, and its levels are increased in infants with heart and kidney disease. Although its physiological and pathophysiological mechanisms are unresolved, recent evidence suggests that the UII system can promote neurotransmission, thereby altering organ function. Here, we…
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