NIH R01 · 2024
L-Type Calcium Channel Mechanisms Mediating Comorbid Substance Use and Mood Disorders
Individuals with substance use disorders (SUDs) have a higher prevalence of mood and anxiety disorders, and those with mood disorders also have a higher prevalence for SUDs. Periods of drug abstinence are also associated with increased irritability, heightened anxiety, and increased mood disorder symptoms. Further, repeated exposure to either drugs of abuse or stress is associated with mood-related disorders. Thus, the comorbidity between substance abuse and mood disorders is an ongoing challenge for the field. There is a need for both improved understanding of mechanisms mediating this comorbidity and a need for novel and effective therapeutic targets. Research continues to reveal…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.