NIH R01 · 2024
ABSTRACT Approximately 60% of patients with obsessive-compulsive disorder (OCD) respond to the psychotherapy of choice, exposure and response prevention (ERP). Unfortunately, troubling symptoms persist for most patients, even treatment responders. ERP is believed to depend on safety learning and engagement of related brain circuitry. OCD patients have repeatedly demonstrated deficits in safety learning and memory processes, but important gaps exist in this literature. In particular, there are limited data on neural functions related to safety learning and memory deficits in OCD. This is important as multiple studies have shown that OCD is associated with dysconnectivity in large-scale…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.