NIH R01 · 2024
Identification of human gut microbe-derived xenolipids: impact of fibers and host metabolic health
Project Summary: The nexus between diet, microbiome, and host involves molecular signals and xenometabolites (“non- self” molecules derived from microbial metabolism) that remain largely unmapped. DNA and RNA sequencing technologies have led to major advancements in understanding how abundances of specific gut microbes correlate to health, diet, and disease; however, the most important information about microbe-host and microbe-microbe communication will emerge from greater understanding of functional outcomes including microbial xenometabolism. To address this knowledge gap, the current proposal will leverage the diversity of innovative human gut bacterial cultures to expand the catalog of…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.