NIH R01 · 2024
Cytoplasmic chromatin fragments in cell senescence - novel mechanisms and interventions
PROJECT SUMMARY Cellular senescence is a cause of cell and tissue aging. Senescence is caused by a range of cellular stresses and characterized by an irreversible proliferation arrest and a potent pro-inflammatory phenotype, the senescence-associated secretory phenotype (SASP). Senescence-associated proliferation arrest and SASP cooperate in tumor suppression, by arresting proliferation of damaged pre-malignant cells and promoting immune clearance of the damaged cells. However, over the longer term, as a source of chronic inflammation, SASP also promotes tissue aging and disease. Consequently, there is currently much effort devoted to development of pharmacologic approaches to eliminate…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.
← All labs at Sanford Burnham Prebys Medical Discovery Institute