NIH R01 · 2024
Regulatory Pathways of SR Protein Kinases
Project Summary/Abstract: The splicing of mRNA is a complex biological process that enormously enhances the diversity of proteins within a limited set of protein-coding genes in the cell. While integral for normal function, errors in splicing can occur and lead to various diseases including muscular dystrophy, Alzheimer's disease, parkinsonism, cardiovascular disease, ataxias and cancers. Splicing relies on essential factors known as SR proteins that bind precursor mRNA and then selectively incorporate other protein/RNA elements ultimately leading to a macromolecular machine known as the spliceosome that performs the necessary excision of certain non-coding elements. The SRPKs are a family…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.