Adams Lab

Stanford University

INTERNAL MEDICINE/MEDICINE

Stanford · United States

NIH-funded
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NIH R01 · 2024

Leveraging machine learning to improve risk prediction for chemotherapy inducedneuropathy

Project Summary/Abstract Chemotherapy-induced peripheral neuropathy (CIPN) affects more than two-thirds of adults with invasive cancer who receive select adjuvant chemotherapies (e.g., taxanes, platinum analogs). Severe CIPN symptoms can lead to chemotherapy dose reductions, treatment delays, or changes in treatment regimens; thereby affecting the potential curative effects of chemotherapy. For some patients, CIPN symptoms can persist over time, contributing to lower quality of life. Little is known about risk factors for CIPN. Chemotoxicity risk scores have been developed and evaluated for use among elderly patients receiving chemotherapy. However, these tools generally report moderate…

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