NIH R01 · 2024
Impact of Zika Virus Infection on Fetal Innate and Adaptive Immunity
PROJECT SUMMARY The objective of this proposal is to define the impact of maternal viral infections and inflammation on immune programming within the fetal brain and lymphoid organs in a well-defined non-human primate (NHP) model. Discoveries in fetal human immunology have primarily come from human cord blood with few studies of fetal blood or the innate immune capacity of major organs. The link between innate immune activation and fetal brain injury is unknown but is of major translational significance to guide novel therapies for fetal protection. Our central hypothesis is that the fetal innate immune programming induced by a maternal ZIKV infection or other infectious triggers initiates…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.