NIH R01 · 2025
The Aqueous Humor Outflow Resistance
Project Summary Glaucoma stands as a formidable adversary in the realm of ocular diseases, chiefly because elevated intraocular pressure (IOP) is both its primary risk factor and the sole controllable parameter. The regulation of IOP is a complex ballet, orchestrated primarily in the outflow pathway by juxtacanalicular (JCT) and Schlemm’s canal endothelial (SCE) cells. These cellular maestros modulate the resistance to aqueous humor outflow, largely through the construction and maintenance of the SCE cells’ expansive basement membrane, a specialized extracellular matrix (ECM). When IOP rises, a cascade of biological responses is triggered, prompting JCT cells to create strategic…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.