NIH R01 · 2025
Phenotype-Tailored Lifestyle intervention for Obesity: A Randomized Trial
PROJECT SUMMARY Obesity is a chronic, relapsing, and multifactorial disease, with a prevalence of 42%. Obesity treatment is challenging in clinical practice because of the physiologic and behavioral adaptations that occur during the weight-reduced state to preserve energy. Our overall goal is to develop an evidence-based, phenotype-guided approach for obesity treatment that enhances weight loss and induces weight loss maintenance despite weight- reduced state adaptations. Our research has identified obesity phenotypes based on energy homeostasis and behavioral traits. Obesity phenotypes include abnormal satiation (i.e., requiring more calories at each meal to achieve fullness), abnormal…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.