NIH R01 · 2025
PROJECT SUMMARY The objective of this proposal is to address the contrast problem in cellular electron microscopy. The cloneable fluorophore, Green Fluorescent Protein (GFP), and related fluorescent proteins complement small molecule stains and dyes to essentially solve the contrast problem in optical imaging. For cellular electron microscopy, however, contrast options are limited and there are no widely used cloneable contrast agents. Cloneable contrast in electron microscope imaging of biology can arise from a `cloneable inorganic nanoparticle (cNP).' A cNP is an NP made by a protein. The protein determines the properties of the nanoparticle such as elemental composition and shape.…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.