NIH R01 · 2024
Transfer RNAs in Hematopoietic Stem Cell Function
ABSTRACT Hematopoietic Stem Cells (HSCs) produce all cells of the blood lineage throughout life. Defects in HSC self- renewal can lead to immunological defects, anemia, and bone marrow failure. Enhanced HSC self-renewal can result in hematopoietic malignancies. Thus, precise regulation of HSC self-renewal is essential for maintaining hematopoietic and human health. Our previous work has shown that adult HSCs tightly control protein synthesis and that modest changes in protein synthesis impair HSC self-renewal and function. However, the mechanisms that regulate mRNA translation in HSCs remain largely unknown. Transfer RNAs (tRNAs) are non-coding adaptor RNAs critical for mRNA translation…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.