NIH R01 · 2025
PROJECT SUMMARY Brain function is dependent on the precise wiring of distinct neuron types into functional neural circuits. Neurons communicate with each other through synapses, which are carefully monitored and supported by specialized non-neuronal cells called glia. Astrocytes are a prominent, peri-synaptic glial cell population that regulates synapse development, synapse stability, and neuronal signaling. As neuronal signaling is an energetically demanding process, one critical function of astrocytes is to support the metabolic needs of neighboring neurons. In the healthy nervous system, astrocytes are known to shuttle lactate directly to neurons to facilitate neuronal respiration and…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.