NIH R01 · 2025
Molecular characterization and modeling efficient antibody effector function
ABSTRACT Antibody effector functions represent a nexus linking innate and adaptive arms of the immune system and also have direct clinical implications for antibody therapeutics and antibody-mediated pathologies. However, the potency of Ab-dependent effector responses depends on numerous antigen, antibody and effector cell properties. Variable antigen expression levels, accessibility and context on different targets influence not only Ab binding but also the ability of the effector cell to kill or engulf its target. Based on the extensive diversity of natural and engineered antibody forms and formats, both B cells and immunologists can engineer antibodies with different flexibility,…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.