NIH R01 · 2025
Non-sputum-based biomarkers for the detection of tuberculosis
PROJECT SUMMARY/ABSTRACT The global spread of Mycobacterium tuberculosis (Mtb) infection continues to pose a significant public health problem, highlighting the urgent need for simple non-sputum-based point-of-care tests (POCTs) to diagnose active tuberculosis (TB) for use in resource-limited settings, a World Health Organization (WHO) priority. Despite substantial efforts, the only commercially available test (Determine™ TB LAM), which uses polyclonal rabbit IgG to detect Mtb lipoglycan lipoarabinomannan in urine (U-LAM), has very low sensitivity in TB patients without AIDS. Moreover, although studies have shown anti-LAM monoclonal antibodies (mAbs) can improve U-LAM detection, sensitivity…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.