NIH R01 · 2024
Structural characterization of Fab-dimerized glycan-reactive antibodies that neutralize HIV-1
Structural characterization of Fab-dimerized glycan-reactive antibodies that neutralize HIV-1 A glycan shield covers the HIV-1 envelope (Env) limiting antibody access to broadly neutralizing antibody (bnAb) epitopes. 2G12 had for long been the only example of a HIV-1 bnAb that interacts solely with the Env glycan shield. Its unique VH domain-swapped architecture, with two Fab arms swapped to create a Fab-dimerized IgG, allows 2G12 to simultaneously interact with 4 glycans, thus bolstering typically weak protein-glycan binding through avidity. We have recently characterized structurally diverse Fab-dimerized, glycan-reactive (FDG) antibodies that target the HIV-1 Env glycan shield. Unlike…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.