NIH R01 · 2024
Mechanisms of Beta Cell Failure
ABSTRACT Aim of this research is to understand why endocrine b-cells in the pancreas of diabetic patients fail, with an eye toward identifying new genetic, biochemical, and cellular pathways that can be exploited as therapeutic targets to prevent and reverse this disease process. This grant has supported several original and widely reproduced discoveries, identifying a homeostatic loop orchestrated by Foxo transcription factors that integrates disparate hormonal and nutrient signals into a gene expression program intended to preserve b-cell function and identity. Signal achievements of this work have been the demonstration of three stages leading to b-cell failure: metabolic inflexibility,…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.