NIH R01 · 2024
Structural basis of apoptotic scrambling
ABSTRACT Every day ~50 billion cells undergo apoptosis, or programmed cell death. Efficient recognition and clearance of these cells is critical for tissue homeostasis in physiology and for its recovery following disease. Initiation of the apoptotic cascade triggers activation of phospholipid scramblases that externalize the lipid phosphatidylserine (PS) in the outer leaflet of the plasma membrane. Recognition of PS by dedicated receptors (PSRs) on immune cells is the first and critical step in the clearance of apoptotic cells. Immune cells with activated PSRs create an immunosuppressive environment that can be exploited by pathogens exposing PS in an immune-camouflage strategy called…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.