NIH R01 · 2025
The Role of Secondary Bile Acids in Gastro-Esophageal Neoplasia
PROJECT SUMMARY Stem and progenitor cells at the gastroesophageal junction (GEJ) have been identified as crucial to the development of adenocarcinoma of the distal esophagus, gastroesophageal junction, and proximal stomach. Combined, these cancers have over 20,000 new cases per year in the U.S., are associated high mortality, and represent a major public health burden. Our group has identified both gastric cardia as well as GEJ transitional basal stem cells as likely cells of origin for precancerous states in this region. However, defining the mechanisms and effectors that drive GE junction stem cell fate and promote cancer development remains a critical gap in knowledge. Barrett’s…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.