NIH R01 · 2024
Suppression of mobile elements by p53 genes
Summary The p53 gene family occupies central positions in stress response networks throughout the animal kingdom and, as transcription factors, these proteins specify robust adaptive responses. Furthermore, the human counterpart is broadly implicated in age-related diseases including most cancers. Yet despite extensive characterization, disease deterrence by p53 is not well understood and conventional explanations for how p53 prevents oncogenic transformation have been fundamentally challenged. Since p53 genes are broadly conserved, ancestral properties of these genes offer promising routes towards understanding functions that become deranged in human diseases. Toward this goal, we built…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.