NIH R01 · 2024
Platelet- mast cell interactions as determinants of the vascular pathology in septic shock.
Abstract: Development of shock in sepsis defines a dramatic deterioration of clinical status and is linked to a significant increase in morbidity and mortality rates. However, the cellular and molecular mechanisms determining the vascular pathology of septic shock remain undefined. Our past work established mast cells (MC) as key effector cells of vascular pathology in different disease contexts. Because MC products are found in the plasma in shock but not during sepsis, this supports that MC activation is a central event leading to septic shock. Employing state-of-the- art technologies such as dynamic photoacoustic imaging of the microvasculature, we provide first evidence that MCs shape…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.