NIH R01 · 2024
Functional outcomes of inflammatory bowel disease associated variants
Project Summary/Abstract The interplay between microbial and genetic susceptibility factors is central to the development of inflammatory bowel disease (IBD). Innate mechanisms, in particular through pattern recognition receptor (PRR) pathways, are the initiating drivers of host responses to microbes. Of the >240 loci associated to IBD, a number of genes modulate host PRR responses at many levels and confer some of the largest genetic effects observed in autoimmunity. Despite the significant recent discoveries in IBD-associated genetics, the functional consequences of the majority of the genetic loci have yet to be identified. A central outcome of PRR activation by microbial products is…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.