NIH R01 · 2024
Extracellular Matrix Regulation of Inflammatory Signaling in Tendon
Abstract Twenty percent of all primary care consults are related to musculoskeletal diseases; 30% of these are associated with tendinopathies. Pathogenesis of tendinopathy includes increased inflammatory signaling and extracellular matrix (ECM) remodeling. This remodeling leads to softer tendinopathic tendons, increasing the risk of tearing. Yet the relative roles of chronic inflammation and ECM stiffness in the initiation and progression of tendon disease remain controversial and are difficult to decouple in patient populations. We and others have shown that, in 2D cell culture using interleukin-1β (IL-1β) as a stimulant, patient-derived tendinopathic fibroblasts exhibit a stronger…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.