NIH R01 · 2025
Using bile salt metabolism to modulate CDI prophylaxis
Abstract Clostridium difficile infection (CDI) is the main identifiable cause of antibiotic assoicated diarreah. in the US alone, there are close to 500,000 cases annually causing approximately 25,000 deaths and costs the health care system an estimated $6.3 billion. C. difficile spores do not cause disease but can revert to toxin-producing bacteria (a process called germination) in the microbiota-depleted gut of hospitalized patients. We found that synthetic cholan-24-amides inhibit C. difficile spore germination and, more importantly, protects rodents from CDI without toxic effects. While amide-linked bile salts have many attractive properties, their hydrolysis can release toxic…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.