NIH R01 · 2024
Epigenetic Mechanisms of Memory Storage
Project Summary / Abstract In the hours after learning, the activation of gene expression follows a specific pattern, producing transient waves of expression needed for long-term memory consolidation. These changes require non-genetic (i.e., “epigenetic”) events, including modifications to: DNA-organizing proteins known as histones, the DNA itself, and the accessibility of DNA to proteins. Additionally, the molecular changes necessary for memory require a form of RNA-based regulation. In the absence of such changes, the long-lasting regulation of gene expression during memory storage fails, and this could account for defects in memory that accompany many psychiatric disorders. Our long-term…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.