NIH R01 · 2025
NNMT Inhibition for treating heart failure
Project Summary Heart failure (HF), spanning from HF with preserved ejection fraction (HFpEF) to HF with reduced ejection fraction (HFrEF), is a leading cause of death worldwide, and among Americans, accounts for 14% of deaths at present. Various pathophysiologic stresses have been clinically and experimentally identified to contribute to HF via distinct molecular mechanisms. However, our limited understanding of the pathogenesis of HF and the poor prognosis of HF strongly underscores the need for further mechanistic investigation and additional therapeutic strategies. Many studies have identified NAD+ deficiency as a central defect in HF of various etiologies. NAD+ deficiency has been…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.