NIH R01 · 2025
Local Delivery of AdipoRon to Treat Arthrofibrosis
ABSTRACT Arthrofibrosis is a debilitating condition that limits joint motion and causes substantial pain. It is a common complication (~5%) following routine total knee arthroplasty (TKA) and its symptoms are often resistant to pharmacological treatments, physical therapy, and revision surgeries. While aberrant extracellular matrix generation is the primary manifestation, the cellular and molecular effectors that trigger and sustain arthrofibrosis have yet to be elucidated. As a result, there are no therapeutic interventions available to prevent or treat arthrofibrosis following TKA. It is thus critical to establish non-surgical preventive and therapeutic modalities for arthrofibrosis. The…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.