NIH R01 · 2025
Therapeutic small molecule modulation of Kv channels
Project Summary Neuronal Kv7 (KCNQ) and Kv1 (KCNA1) subfamily voltage-gated potassium (Kv) channel loss-of-function causes developmental epileptic encephalopathy, ataxia, hereditary spastic paraplegia (HSP) and addiction. In this project we focus on the mechanistic basis and potential therapeutic utility of plant-derived diterpenes and hydroxybenzoic acids that are extremely well tolerated in rodent and human safety studies, cross the blood- brain-barrier, and which we recently discovered to be potent, efficacious openers of neuronal Kv7 and Kv1 channels. Addiction and epilepsy represent major health burdens in the US and globally, and new approaches to their treatment are desperately…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.