NIH R01 · 2025
Functional regionalization of the brain revealed by multi-modal neural and genomics data integration
Project Summary/Abstract In the past decade, genome-wide characterization of gene expression in cells dissociated from biological tissues has transformed the understanding of cell types that build organs in a variety of organisms. However, to define the precise arrangement of cell types within a tissue or organ, analysis of large-scale spatial transcriptomics and integration with other spatial datasets such as neural connectivity patterns is needed. To achieve these integrative analyses of multiple highly dimensional datasets (e.g., hundreds of genes in cellular resolution, measured across the whole organ), all datasets need to be brought together in the same common coordinate system and…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.