Oudenhove Lab

University of Leuven

Vlaams Gewest (BE2) · Belgium

ERC-funded
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ERC Consolidator Grant · 2020

How our gut microbes influence how we feel – bacterial metabolites and inflammation as mediators of human microbiota-affect relationships

Do our gut microbes influence our emotions? This sounded far-fetched a decade ago, but rodent research has shown that the microbial ecosystem in the gut (the gut microbiota) causally impacts affective processes. The underlying microbiota-gut-brain signalling mechanisms include the capacity of the microbiota to produce short-chain fatty acids (SCFA) from dietary fiber and to regulate inflammation. These rodent findings have great potential to identify new modifiable players in the (patho)physiology of affective processes and disorders, which is urgently needed given the stalled revolution in affective science, but human translation is needed to fulfill this potential. MoodBugs aims to fill…

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