Cools Lab

Radboud University Medical Center

Oost-Nederland (NL2) · Netherlands

ERC-funded
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Research focus

ERC Advanced Grant · 2021

Balancing brain chemicals for boosting meta-control

Cognitive control enables us to flexibly adapt behaviour to achieve our goals given a constantly changing environment. It is a hallmark of the human mind and exquisitely vulnerable in health and disease. Cognitive control often implies goal-directed instrumental effort to inhibit unwanted, yet hardwired or overlearnt biases, and is commonly associated with the prefrontal cortex (PFC) and dopamine (DA). However, the mechanisms of the broader construct of flexible cognitive control remain unclear. The urgency of addressing this is evidenced by robust predictive associations between flexible control and consequential life outcomes for health, wealth and well-being. CHEMCONTROL approaches the…

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