Hartwigsen Lab

University of Leipzig

Sachsen (DED) · Germany

ERC-funded
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ERC Consolidator Grant · 2021

The Flexible Brain: (Re-)shaping Adaptation in Semantic Cognition

The human brain is flexible. Neural networks adapt to cognitive demands by flexibly recruiting different regions and connections. Flexible network adaptation enables cognitive functions such as semantic cognition: the ability to use, manipulate, and generalize knowledge. When key nodes suffer damage, networks can adapt to recover function. Yet, brain lesions often severely impair semantic cognition. How the semantic network adapts to lesions is poorly understood. My hypothesis is that disruption of the semantic network can be compensated for by recruitment of domain-general networks. This notion is based on findings that disruption of semantic nodes inhibits semantic activity but increases…

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