Andrillon Lab

National Institute of Health and Medical Research (INSERM)

Ile-de-France (FR1) · France

ERC-funded
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ERC Starting Grant · 2023

Sleeping While Awake: Sleep intrusions during wakefulness and their cognitive consequences

What happens in our brains when we get tired? Mental fatigue can occur for diverse reasons, through extended periods of wakefulness or following intense cognitive efforts. In other words, fatigue can be both time and use-dependent. My core hypothesis is that both processes are underpinned by local intrusions of sleep in the awake brain. Sleep and wakefulness are not mutually exclusive states. When animals are sleep deprived, high-amplitude slow waves (SWs), a hallmark of sleep, can be locally observed in awake individuals. These wake SWs have been linked to impaired cognitive performance. I have further shown that these wake SWs can be observed without sleep deprivation when participants…

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