Sprooten Lab

Radboud University Medical Center

Oost-Nederland (NL2) · Netherlands

ERC-funded
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ERC Consolidator Grant · 2024

Environment-Mediated Genetics: The Power of Biological Non-Determinism for Mental Health

Mental health problems are associated with variation in the brain and genome. The mechanisms underlying these associations are extremely hard to discern because they are subtly distributed across thousands of genes and not specific to neural processes. Meanwhile, a focus on biology tends to induce feelings of helplessness among those affected by mental health problems, as biology is typically seen as deterministic. I propose that both our mechanistic understanding and the sense of personal agency will leap forward if we consider modifiable, heritable social and lifestyle factors (i.e. "environment") centrally within the causal chain from genes to brain to mental health. Environmental…

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