Salami Lab

Karolinska Institute

Östra Sverige (SE1) · Sweden

ERC-funded
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ERC Consolidator Grant · 2024

Unlocking the Dynamics of Dopamine in Aging: Balancing Pre- and Post-Synaptic Mechanisms for Optimal Brain Function across the adult lifespan

Many older adults experience impairment of cognitive functions, such as memory. While changes to the aging brain are often assumed to underlie cognitive decline, but it has turned out surprisingly hard to identify coupled brain-cognitive changes in aging. This challenge is magnified when searching for potentially modifiable brain alterations that could serve as targets for various kinds of interventions. A promising candidate mechanism is age-related alterations in neurotransmitters like dopamine (DA) and noradrenaline (NA), crucial for brain functions. Yet, existing models of aging related to DA and NA are inadequate, as past studies solely focused on either the DA or NA system and also…

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