Folloni Lab

Vita-Salute San Raffaele University

Nord-Ovest (ITC) · Italy

ERC-funded
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ERC Starting Grant · 2025

Neural Mechanisms and Non-invasive Deep Brain Stimulation of Mood and Well-being

Our expectations about the world shape our mood and well-being. In extreme contexts, mood can become pathologically depressed as in mood disorders or dementia. Recent studies have begun to suggest a mechanism for how expectations (and their violation) impact human moods. Unfortunately, this mechanism relies on correlational studies since we currently lack tools able to directly manipulate these circuits in healthy humans. UltraDeepMood will combine cutting-edge ultrasound stimulation with imaging and computational modeling to determine the hypothesis that human moods can be changed by modulating expectation signalling in deep brain subcallosal cingulate circuits. UltraDeepMood will overcome…

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