Mazzotti Lab

Swiss Federal Institute of Technology Zurich (ETH Zurich)

- · Switzerland

ERC-funded
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Research focus

ERC Advanced Grant · 2017

Studying Secondary Nucleation for the Intensification of Continuous Crystallization

Many products in the chemical, food and pharmaceutical industry are produced as powders through a crystallization process. Continuous crystallization has been for decades the process of choice for large-scale production, for instance of sugar, table salt, adipic acid, and has become more recently a key component of the new paradigm, i.e. the continuous manufacturing of active pharmaceutical ingredients. All product crystals of continuous crystallization processes are formed through secondary nucleation, which is both ubiquitous and elusive. Research has left several key questions unanswered, such as about where and how secondary nuclei are formed, either from the parent crystal due to…

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