ERC Starting Grant · 2017
SENSING CELL-CELL INTERACTION HETEROGENEITY IN 3D TUMOR MODELS: TOWARDS PRECISION MEDICINE
This project aims to investigate the role of potassium (K+), protons (H+) and oxygen (O2) gradients in the extracellular space of tumour cells grown in 3D cultures by using a combination of imaging, cell biology and in silico analyses. By embedding ratiometric fluorescent particle-based sensors within 3D scaffolds, the changes in target analyte concentrations can be monitored and used to study the interactions between tumour cells and stromal cells in 3D tumoroids/scaffolds and to monitor response of the cells to drug treatments. I was the first to demonstrate successful fabrication of barcoded capsules for multiplex sensing of H+, K+, and Na+ ions. Next, I demonstrated the use of…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.