Macchia Lab

University of Bari Aldo Moro

Sud (ITF) · Italy

ERC-funded
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ERC Starting Grant · 2021

A binary sensor with single-molecule digit to discriminate biofluids enclosing zero or at least one biomarker

Biomarkers are measurable indicators of a particular disease state of an organism. There has been an increasing demand for diagnostic markers, enabling reliable and non-invasive screening of peripheral biofluids. It is also established that a universal screening against life-threatening diseases, such as cancer, or infectious disease outbreaks, can be accomplished only by combining genomic and protein marker-based tests. The NoOne project aims at conceiving, engineering, fabricating and validating a ground-breaking platform based on a single-molecule binary bioelectronic sensor, capable to reliably discriminate biofluid samples enclosing zero biomarkers from those containing just one. The…

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