Monaghan Lab

Trinity College Dublin

Ireland (IE0) · Ireland

ERC-funded
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ERC Consolidator Grant · 2023

Piezoceutical biomaterial scaffolds for immunomodulatory-based myocardial repair

Cardiac injury in the form of a myocardial infarction leads to cardiac muscle death and replacement scar tissue that cannot compensate lost heart tissue. This disease does not improve with traditional drugs and places significant burden on healthcare budgets worldwide; with a reduced quality of life for patients, often leading to heart failure. Current engineered cardiac patches do not reduce inflammation and do not integrate in a sufficient manner to compensate the pumping power lost with the heart tissue. The PiezoMac patch differs fundamentally from patches reported up to now. It will contain an optimised piezoelectric capability that will yield electric fields generated by the…

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