Conti Lab

University of Pavia

Nord-Ovest (ITC) · Italy

ERC-funded
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ERC Consolidator Grant · 2023

Redesigning aortic endograft: enabling in-situ personalized aneurysm healing

Forty years ago, the endograft (EG) enabled the endovascular treatment of aortic aneurysm (AoA) and revolutionized vascular surgery. Still, since then, its technological concept has remained substantially unchanged: EG is a passive device aimed at treating the AoA in its late stage, not to cure the disease, even when discovered early. This proposal introduces a bio-engineered process to redesign EGs as 3D bio-printed, bioresorbable devices loaded with active drug components and validated in-vitro to enable the paradigm shift: from end-stage treatment to early personalized healing. To this aim, EPEIUS must tackle three open challenges: 1) available (animal) models often fail to predict human…

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