Gagliano Lab

University of Padua

Nord-Est (ITH) · Italy

ERC-funded
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ERC Starting Grant · 2023

Engineering the Origin of Human Shape: Defining Patterns and Axes in the Early Stage of 3D Pluripotency

How an organism takes shape is a longstanding challenHow an organism takes shape is a longstanding challenge in modern biology and medicine. Understanding how, during the 3D embryo development, different molecular players, such as genetic programs, morphogens, and forces work together to build the shape of the body is still far to be understood, especially for humans. In recent years, some progress has been made to understand the inaccessible state of human development through models of human embryos derived from pluripotent stem cells. Although they brought very exciting findings, this approach failed in reconstructing the dynamic of the proper axes formation and 3D spatially ordered…

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