ERC Starting Grant · 2025
Predicting the Regeneration of an Infarct by leveraging the Mechanobiology of Angiogenesis
Acute myocardial infarction (AMI) is a significant global health issue. Current therapies cannot regenerate the hearts of survivors, leading to frequent AMI recurrence and premature death. Crucially, these therapies fail to induce sufficient blood vessel formation, i.e. angiogenesis, which is essential to regenerate the cardiac microvasculature. Without this vasculature, cells repopulating the infarcted tissue cannot survive. A deeper understanding and better control of post-AMI angiogenesis would thus transform patient outcomes. Cells in the infarcted heart experience complex, time-evolving mechanical environments. Despite the proven role of mechanical stimuli in regulating angiogenesis in…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.