ERC Consolidator Grant · 2017
Microsystems for Cryomicroscopy
This proposal aims to revolutionize time-resolved light and electron cryo-microscopy of fast cellular dynamics using a new class of cryogenic microsystems for the reversible cryofixation of cells and small model organisms by ultra-rapid cooling. This will contribute to our understanding of biological structure and function by revealing the dynamics of specific proteins in the ultrastructural context of a cell at nanometer spatial and millisecond temporal resolution. Despite rapid progress in the field, much of the potential of microscopy at cryogenic temperature today is still untapped due to limitations in methods and instrumentation for sample preparation. First, vitrification…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.