Vicidomini Lab

Italian Institute of Technology

Nord-Ovest (ITC) · Italy

ERC-funded
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ERC Consolidator Grant · 2018

Multi-Parameter Live-Cell Observation of Biomolecular Processes with Single-Photon Detector Array

Fluorescence single-molecule (SM) detection techniques have the potential to provide insights into the complex functions, structures and interactions of individual, specifically labelled biomolecules. However, current SM techniques work properly only when the biomolecule is observed in controlled environments, e.g., immobilized on a glass surface. Observation of biomolecular processes in living (multi)cellular environments – which is fundamental for sound biological conclusion – always comes with a price, such as invasiveness, limitations in the accessible information and constraints in the spatial and temporal scales. The overall objective of the BrightEyes project is to break the above…

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