Bon Lab

National Centre for Scientific Research (CNRS)

Ile-de-France (FR1) · France

ERC-funded
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ERC Starting Grant · 2019

Label-free quantitative nanoscopy for molecular specific identification at depth in pristine living biological tissues

Optical microscopy has undergone a revolution that now allows us to access molecular resolution (“nanoscopy”) with the identification of specific biomolecules within biological samples. Nanoscopy has become a key approach to decipher the function of living matter since biomolecules are the elementary building blocks. While being a major tool, high-resolution and specificity can only be achieved by tagging the molecules of interest with fluorescent probes, which inevitably alters the samples, making them improper for medical applications including regenerative medicine. The leading dogmas being that (i) nanoscopy cannot be achieved without labelling and (ii) no specific signature from…

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