Joita-Pacureanu Lab

European Synchrotron Radiation Facility

Auvergne-Rhône-Alpes (FRK) · France

ERC-funded
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ERC Starting Grant · 2019

Bright, coherent and focused light to resolve neural circuits

The overarching goal of this project is to establish a novel technique for neuroimaging to probe large tissue volumes at the nanometre scale. Currently only electron microscopes are capable of generating data with sufficient resolving power for comprehensive exploration of the neural circuits that underlie brain function. With state of the art systems, imaging just one cubic mm of brain entails years of data collection, ultra-thin sectioning which is prone to errors and data loss, and prohibitive costs. Each circuit unit spans over large distances, thus access to millimetre sized volumes of view is essential for both fundamental and therapeutic discoveries in neurosciences. Today this is an…

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