ERC Advanced Grant · 2021
Foldable, REconfigurable & Jagged devices for enhanced drug Absorption/seeding
Oral delivery of protein/peptide drugs is extremely challenging and the majority of research in the field is based on exploring new formulations, for instance using permeation enhancers. In recent years, some research has been done on ingestible devices for internal injections. Here I propose an entirely new approach based on what we have named ‘Self-configurable, Proximity Enabling Devices’ (SPEDs). The idea is that these devices (the simplest ones will be rolled-up foils) will unfold in the gut, embed in the mucus layer and align to the intestinal wall. It is essential that the SPED has close proximity to the intestinal wall and is retained for a while in order to ensure efficient drug…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.