Ionescu Lab

Ghent University

Vlaams Gewest (BE2) · Belgium

ERC-funded
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ERC Consolidator Grant · 2021

Adaptive Multi-Drug Infusion Control System for General Anesthesia in Major Surgery

A major challenge in anesthesia is to adapt the drug infusion rates from observed patient response to surgical stimuli. The patient models are based on nominal population characteristic response and lack specific surgical effects. In major surgery (e.g. cardiac, transplant, obese patients) modelling uncertainty stems from significant blood losses, anomalous drug diffusion, drug effect synergy/antagonism, anesthetic-hemodynamic interactions, etc. This complex optimisation problem requires superhuman abilities of the anesthesiologist. Computer controlled anesthesia holds the answer to be the game changer for best surgery outcomes. Although few, clinical studies report that computer based…

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