Acconcia Lab

Polytechnic University of Milan

Nord-Ovest (ITC) · Italy

ERC-funded
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Research focus

ERC Starting Grant · 2023

High-speed timE Resolved fluorescence iMaging with no pilE-up diStortion

The overarching goal of HÈRMES is to establish a new methodology for time-resolved imaging by means of Time-Correlated Single Photon Counting(TCSPC). Since its debut in the literature, the potential of TCSPC as non-invasive, ultra-sensitive and extremely precise imaging tool was manifest. Numerous applications have benefited from it so far, but a key limitation still prevents its wide use in many other crucial applications: the speed of a TCSPC acquisition chain must be kept low(few Mcount/s in the best case) to avoid distortion due to pile-up of events. Up to now researchers in this field have tried to work around this limit mainly by posing multiple channels in parallel, but still facing…

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